Botox
Type A botulinum toxin strain was approved by FDA in 1989 under the name Botox for the treatment of spasms. Approval for the treatment of cervical dystonia and glabellar lines followed. Today Botox is used not only for smoothening wrinkles but also in case of temporomandibular joint disorders, tension-type headaches, bruxism, excessive gingival display, orthodontic relapse due to severe muscle movement, sialorrhea, trigeminal neuralgia, and hemifacial spasms (and oromandibular pain).